quarterback is out for the season after sustaining a right shoulder injury during Monday's practice, a source told ESPN's Brett McMurphy.
Miller had an MRI on his throwing shoulder Tuesday morning, revealing the season-ending injury.
More from ESPN.comThe impact of Ohio State losing QB Braxton Miller will be felt not only in Columbus, but throughout the entire Big Ten, writes Brian Bennett. Meet QBs J.T. Barrett and Cardale Jones. Ohio State's future is in their hands now, writes Austin Ward.
Widely tabbed as a Heisman Trophy contender this preseason, Miller suffered the injury during a noncontact portion of practice, just hours after the senior declared himself 100 percent healthy following offseason surgery to the shoulder. He was taken off the field under medical supervision, a source told ESPN on Monday.
Miller threw for 2,094 yards and 24 touchdowns and ran for 12 more scores in leading the Buckeyes to the Discover Orange Bowl last season.
Ranked fifth in the preseason Associated Press poll released Sunday, Ohio State is expected to be in the national title conversation.
The reigning two-time Big Ten Offensive Player of the Year, Miller first hurt the shoulder in the Orange Bowl. He had surgery that prevented him from contact in spring practice and was held out of several practices and scrimmages in August.
Redshirt freshman is expected to be the starter when the Buckeyes open the season Aug. 30 against in Baltimore. Ohio State coach Urban Meyer said Saturday that redshirt sophomore is the third-team quarterback.
Miller is one of the Big Ten's most decorated quarterbacks, and the falloff in experience to Barrett and Jones is huge.
Miller Among Top Returning QBs
Braxton Miller was one of the top returning starters in the nation. He ranked 13th in Total QBR last season, which was seventh among all returning FBS starters.
Highest Total QBR For Returning FBS Starting QBs